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In Phase 3 studies: Participants without diabetes taking orforglipron lost approximately 9% to 10% of body weight over roughly 36 to 40 weeks Participants with type 2 diabetes generally lost around 7% to 8% By comparison, Wegovy's landmark STEP trials reported approximately 14.9% average weight loss over 68 weeks

Human skin-specific trials are lacking, but users anecdotally report improvement in inflammatory skin conditions

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The National Institute on Drug Abuse is sponsoring a clinical trial this year evaluating tirzepatide, the active ingredient in Eli Lillys weight-loss drugs, as a potential treatment for cannabis use disorder