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However, it requires a prescription and may carry side effects, including an increased risk of blood clots and breast cancer

A 2026 UK review of the October 2025 Neurology study linking high intake to ~62% faster cognitive decline, the aspartame methanol/phenylalanine/microglia neuroinflammation and BDNF/TrkB mechanism, the 2025 University of Colorado erythritol blood-brain-barrier and stroke study, the reverse-causation trap, the WHO/IARC verdict and the UK sugar-tax reformulation angle versus Dihexas unproven HGF/c-Met synaptogenesis, and why switching to water beats a peptide Read the full review NewNutrition, Metabolic & Cognitive Neuroscience 8 July 2026 Dihexa for Keto & Low-Carb Brain Fog: Ketones, the Keto Flu, BHB & the 2026 UK Review Does keto cause brain fog or clear it

Further references were identified by searching the reference lists of retrieved articles and from the authors' knowledge of the field

Statements Author contributions NC: Writing original draft, Conceptualization, Data curation, Visualization

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Prescription GLP-1 medications are usually taken once weekly, following medical guidance (15,16,17)