The controversy in the news right now is not about those approved medications
47 The expression of NPY in ARC neurons is lowered after central or systemic administration of leptin and insulin, but these NPY neurons are activated when the levels of these hormones decrease during undernutrition
Goodrick JC, Xu M, Finnegan R, Schilling BM, Schiavi S, Hoppe H, Wan NC (2001) High-level expression and stabilization of recombinant human chitinase produced in a continuous constitutive Pichia pastoris expression system
Normal cerebrospinal fluid glutathione concentrations in Parkinson's disease, Alzheimer's disease and multiple system atrophy
10.1172/jci.insight.141851 21 SandovalD
As people used Topamax more widely in the 2000s, users began to report various side effects