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Direct human evidence at the dihydroberberine level remains limited

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While a risk of cholelithiasis with oral semaglutide thus remains uncertain, an increased risk of cholelithiasis has previously been reported for GLP-1RAs in a meta-analysis of trials with these agents [Citation34]

In some cases, depending on the formulation and provider, there may be oral versions such as tablets or drops

This can account for the presence of hyperkalemia observed in ~1/3rd of patients with DKA (Adrogu et al, 1986

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