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Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase
Aliment Pharmacol Ther 50(2):193203
In clinical trials, the most common observations were gastrointestinal effects: nausea (44.2% vs 17.4% placebo in STEP 1), diarrhea (30.0%), vomiting (24.8%), and constipation (24.2%)
Liquid protein and structured meals help when hunger is essentially absent
Monitor for side effects : Pay attention to any side effects after missing or taking a delayed dose
Include any over-the-counter medications, supplements, or herbal remedies
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