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Besides, germ-free mice or antibiotic-induced mice can enhance central nervous sensitivity to leptin mediated by GLP-1RA (27).In contrast, mice supplemented with probiotic strains, such as Lactobacillus , can promote GLP-1 secretion (8688)

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Downregulation of GLP-1R by siRNA silencing attenuated GLP-1(3236)induced cGMP increase and NO formation (Figure 8A and 8B), suppressed GLP-1(3236)stimulated phosphorylated eNOS and PKG expression (Figure 8C through 8E), and antagonized GLP-1(3236)mediated improvement of tube formation and migration in response to HG treatment (Figure 8F through 8I)

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