Tirzepatide is a unique dual RA of both the GLP-1 and GIP receptors, which significantly reduces HbA1c levels and body weight in patients with T2DM and obesity
Front Pharmacol 15:1347047 Nabrdalik K, Skonieczna-ydecka K, Irlik K, Hendel M, Kwiendacz H, oniewski I, Lip GY (2022) Gastrointestinal adverse events of Metformin treatment in patients with type 2 diabetes mellitus: A systematic review, meta-analysis and meta-regression of randomized controlled trials
Initial in vivo testing with GEP12 (5 and 10 mg/kg/day) resulted in robust reductions in food intake and body weight, albeit somewhat less than responses observed in rats treated with equivalent doses of GEP44 (Figs
Sheehy, E.B
The medication slows gastric emptying and may affect absorption of oral medications, requiring additional contraception for 4 weeks after initiation and dose increases
GLP-1 Medications GLP-1 medications have changed the conversation around weight management and type 2 diabetes