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A study by our group suggested that chronic irAEs may occur in as many as 43.2% of patients treated with anti-PD-1 in the adjuvant setting.21 Herein, we will explore the pathophysiology of chronic irAEs, their relevance to different organ systems, treatment approaches, and briefly discuss other long-term complications of ICI.

Sachan DS, Rhew TH, Ruark RA: Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver

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The Inhibition of 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase 2010 1

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It is a functional signal of how the gastrointestinal regulatory system responds