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Several pathways have been found by which ROS promotes damage and disassembly of meiotic spindle microtubules in oocytes ( 64 ): Stability of the spindle is dependent on maintaining the dynamic equilibrium between polymerization (assembly) and depolymerization (disassembly) of tubulin subunits to maintain intact spindle microtubules

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Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression

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Given their effects on different hormone pathways, using them together may increase the potential for side effects and unpredictable interactions