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NPY/Y(1) receptor-mediated vasoconstrictory and proliferative effects in pulmonary hypertension

Concomitant use of weight-promoting medications, such as insulin or sulfonylureas, may further blunt the weight loss effects of GLP-1 RAs [45]

Schoretsanitis and Gastaldon found that patients who are co-prescribed antidepressants and the GLP-1 agonist semaglutide may be at risk of developing suicidal ideation

Important caveat: TRIUMPH-4 enrolled participants with obesity plus knee osteoarthritis, not a general obesity population

Switching from Dulaglutide or Liraglutide to Semaglutide did not lead to a significant impact on HbA1c levels

Hypothalamic neuronal preparations characterise the compound's effects on appetite-related circuits in the arcuate nucleus (POMC and AgRP neurons) and the paraventricular nucleus