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To address not only the unwanted texture, but also the pigmentation, inflammation, and barrier issues found in KP, we need to identify substances that can reduce the effects seen from IGF-1 deficiency and IR mutations in skin tissue

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In diabetic nephropathy, podocyte NOX4derived HO drives podocyte injury and slit-diaphragm defects, thereby promoting albuminuria [345], whereas in diabetic retinopathy PKC-driven and VEGF-driven permeability changes are tightly linked to oxidative stress [346]

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Diabetes 53 , 535-P (2004)