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To view or add a comment, sign in For nearly two decades, enzyme replacement therapy (#ERT) for #MPS-I has meant essentially one thing: a weekly, hours-long intravenous infusion that sustains patients but leaves two territories almost untouched the brain and the bone

Consistently, WT AMPK overexpression rendered DM-succinate-treated or ITA-treated cells less sensitive to glucose starvation (Fig

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Thus, those on stable products may not be quick to switch, and tirzepatide is still a weekly injection versus oral treatment option