Long-term effects and interactions with other medications remain unexamined
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2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation
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Unusual symptoms such as acne-like skin reactions or hypokalaemia (low potassium) during initial high-dose treatment are rare but should prompt medical consultation
Ferroptotic foam cells release substantial inflammatory mediators, including IL-1 and IL-18, which belong to the IL-1 cytokine family and undergo caspase-1-mediated activation (48, 49)