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Intracellular staining was performed using a Fixation and Permeabilization Buffer Set (eBioscience, 88-8824-00), according to the manufacturers instructions, and included antibodies specific to ARG1-APC (clone A1exF5, Invitrogen, 17-3697-82, 1:100) and iNOS-PE (clone CXNFT, Invitrogen, 12-5920-82, 1:100) or isotype control rat IgG2a -APC (clone eBR2a, Invitrogen, 17-4321-81, 1:100) and rat IgG2a -PE (clone eBR2a, Invitrogen, 12-4321-41, 1:100)

Therapeutic relevance of Tirzepatide Exploitation of GLP-1R and GIPR signaling has driven the development of dual-receptortargeted therapies

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In 2021, the FDA approved semaglutide (Wegovy) for chronic weight management in adults who are overweight or obese

Activation of these receptors has been shown to modulate the production of pro-inflammatory cytokines and promote anti-inflammatory pathways