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Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian Network Meta-Analysis

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There are three main mechanisms relevant to Canadian patients today, plus a group of older drugs that have largely fallen out of use: GLP-1 and related incretin drugs These mimic gut hormones that regulate appetite and blood sugar, reducing hunger and slowing digestion

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Some of it is absolutely in our control, but factors like genetic predispositions may not be

The dual agonism targets both GIP and GLP-1 pathways, which are key incretin hormones involved in glucose regulation