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CSF-to-plasma concentration ratios above 10% indicate significant CNS activity this assay should precede any combination protocol with antidepressants

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Bibcode:1980Natur.288..715P

Discussion The ability of integrins, clustered within matrix adhesion sites, to regulate signal transduction pathways that not only modulate cell adhesion and motility but also gene expression has been the subject of numerous studies 1,2,3,4,5,6,9,10,11,12,27,28,47