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Programa de estudio de fase III SURPASS La muestra de sujetos incluidos en los estudios SURPASS 1-5 representa un amplio espectro de caractersticas de los pacientes y situaciones de tratamiento en la diabetes tipo 2 de [610]
Maximum dose: 400 mg per day, given as 200 mg twice daily , for those not responding to 300 mg/day
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When combined with insulin or sulfonylureas, dose adjustments may be needed to prevent hypoglycaemia
cAMP accumulation assay is conducted as described in the text, and the binding assay was carried out using radiolabelled GLP-1 as a tracer and competing it with a serial dilution of unlabelled GLP-1
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