Further, mixing arcitgenin with other bioactive compounds has demonstrated a synergistic effect in bioavailability, and hence efficacy, in cancer models, including green tea, curcumin, and quercetin in combination [91, 92]
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The anti-cancer properties of biguanides are displayed through several mechanisms of action, including the activation AMPK pathway with the consequent inhibition of mTOR and reduction of several pro-tumorigenic effects including cell proliferation and production of inflammatory mediators (Seyfried et al., 2014
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