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2010 Mar 3;15(3):1242-64. [PMID: 20335977]
Certainly, an increase in IGF-1 action is associated with greater risk for neoplastic disease, a link further supported by this study and others targeting IGF-1Rs, but IGF-1 has been paradoxically associated with protection against osteoporosis, type 2 diabetes, cerebrovascular and cognitive decline in pre-clinical studies, as well as in some human epidemiologic studies 12
Third, the context-dependent duality of ferroptosis is evident: it can facilitate pathogen spread by eliminating immune surveillance cells or conversely restrict infection by clearing infected cells
Regular follow-up should include assessment of weight loss trajectory, tolerability, medication adherence, and renal function if significant GI symptoms occur
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