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Supriya Rao, MD, is a quadruple board-certified physician in internal medicine, gastroenterology, obesity medicine, and lifestyle medicine who focuses on digestive disorders, gut health, the microbiome, obesity medicine, and women's health.

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The semaglutide versus tirzepatide comparison page breaks down how these dose-response curves differ between the two most popular GLP-1 medications

People may microdose GLP-1 medications for many reasons, including: They have hit their target weight goal They have concerns about the cost of the medications They are sensitive to the side effects of the medications They want to just suppress their appetite They are worried about the supply of the medications Microdosing GLP-1 medications can come with real risks, including: Inaccurate doses Reduced effectiveness Unpredictable outcomes Possibility of regaining weight No data on the long-term effects of microdosing Minimal oversight Large clinical trials have confirmed that the standard GLP-1 doses work well when helping people lose weight and manage Type 2 diabetes

Weight loss typically plateaus or slows between months 36 as the body adapts to the medication and calorie deficit stabilizes

Healthcare providers determine what dosage of Ozempic to prescribe based on which condition it is intended to treat, the patients treatment goals, and how well the patient is responding to the medication