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d , Fold change (log 2 ) in indicated whole cell or ER metabolites from ER-tag HEK293T cells treated with antimycin compared to untreated

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In terms of onset, the oral form may take slightly longer to produce noticeable effects because of its lower and more variable bioavailability

Transition metalbased carriers (e.g., MnO, Cu 2 , Fe 3 ) provide an additional layer of functionality, as they can both deplete intracellular GSH and generate reactive oxygen species, thereby amplifying oxidative stress within tumors