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This treatment should be provided within specialist weight management services, is typically time-limited (generally up to 2 years), and must be part of a comprehensive programme including dietary modification, increased physical activity, and behavioural support
Patients who reach their goal weight on 0.5mg can maintain results long-term at that dose, while those with stalled progress after 6-8 weeks typically benefit from moving to the next dose tier
PIONEER 3: Head-to-head vs Januvia (sitagliptin) 1,4 Study design: 78-week, randomized, double-blind, double-dummy, active controlled, parallel-group, phase 3a trial designed to assess the efficacy and assess long-term adverse event profile of once-daily semaglutide tablets vs Januvia in addition to metformin with or without sulfonylurea
Pituitary 24 , 887903
Therefore, more research is necessary to validate findings from preliminary and small scale studies
Malaguarnera, Mariano, et al
