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Conclusions These findings hold promise for the development of effective weight loss interventions in this population group

Sitagliptin, a DPP-4 inhibitor, enhances early insulin secretion by reducing incretin and GLP-1 degradation, reduces peak glucose after oral glucose intake in overweight women with PCOS, and improves visceral obesity [169]

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The molecular targets (receptors) are the same

Targeted induction of ceramide degradation leads to improved systemic metabolism and reduced hepatic steatosis

Yet cardiomyocytes, the main muscle cells of the heart, and hepatocytes in the liver do not appear to express GLP-1 or GIP receptors in significant amounts