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Sip fluids slowly, particularly if experiencing nausea, as small frequent amounts are often better tolerated than large volumes

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209,210,211,212,213,214,215,216 The second signal triggers NLRP3 activation, leading to the assembly of the inflammasome, proximity-induced autoproteolysis of caspase-1, and the subsequent cleavage of IL-1, IL-18, and GSDMD

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The titration schedule starts at 2 mg per week for 4 weeks, escalates to 4 mg for weeks 5 through 8, then to 8 mg for weeks 9 through 12, and reaches the 12 mg maintenance dose at week 13 (Jastreboff et al., NEJM 2023)