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The extension included 532 participants among eligible completers who had a baseline BMI greater than 35 and were on-target dose at 80 weeks

doi:10.1016/j.peptides.2024.171271 126

Isr Med Assoc J

This gradual dose escalation helps minimize gastrointestinal adverse effects

(PubMed) Smith A, Clark R, Nutt D, Haller J, Hayward S, Perry K

Experimental investigations have demonstrated that cholangiocytes are sensitive to GLP-1 and respond with augmented proliferation, potentially increasing the risk of duct obstruction [47,48]