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In some cases, like acetaminophen overdose, the mechanism is well established
As we age, the natural production of these peptides declines, contributing to common signs of aging and slower recovery
Furthermore, RNAi-mediated suppression of SNX proteins, the core retromer component VPS29, or the RAB7 activator MON1, as well as the expression of dominant-negative mutants of RAB5 and RAB7 (ARA7 S24N and RABG3f T22N ), redirected GFP-VSR2 to the vacuole for degradation (Fig
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