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Phentermine is not safe for people with heart disease, uncontrolled hypertension, glaucoma, hyperthyroidism, a history of drug abuse, or agitated states

Alzheimer's & Dementia Journals+2The Lancet+2 A meta-analysis pooling many clinical trials (though mostly for diabetes endpoints) suggested that GLP-1 RAs (versus placebo or other drugs) may reduce risk of dementia among diabetics

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Obesity is also linked to an increased risk of certain types of cancers