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15,16 Additionally, Phe 1 exenatide shows stronger long-term insulin release (which is dependent on -arrestin recruitment reduction), faster agonist dissociation rates and lower receptor internalization than exenatide

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Comparative work with selective MC4R agonists (bremelanotide) and selective MC3R agonists helps dissect the individual contributions of these receptor subtypes to integrated energy balance regulation

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doi: 10.2337/db06-0565, 123 RavandiB.IspirovaG.SebekM.MehlerP.BarabasiA