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1 They act on the GLP-1 receptors in the brain to process signals that reduce hunger

16 The rapid pace of weight loss often achieved with GLP-1 medications may contribute significantly to the concern surrounding muscle loss

CT-996, a once-daily oral, small molecule GLP-1 receptor agonist currently in Phase-1 trials for treating obesity in patients with and without type 2 diabetes

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Koeth et al

However, chronic ultra-processed food consumption, sedentary behavior, and insulin resistance can blunt these natural signals over time