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Such stress-associated -cell states are known to display impaired incretin responsiveness due to reduced GLP1R signaling and diminished cAMP pathway activation (Luo et al., 2013)[Gao], suggesting that inflammatory axes linked to dysbiosis may differentially affect vulnerable -cell subpopulations

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This appears to also result in reduction of pro-inflammatory cytokines such as IL-1 and IL-18 in macrophages and mice 48

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