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Lactate also acts on these immune cells epigenetically by increasing H3K9 acetylation in macrophages at genes like ARG1 and Retnla, reinforcing M2 gene expression and locking TAMs into an M2 polarized state (61)

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Acknowledgments The authors thank the staff of Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases

Trends in Endocrinology and Metabolism