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Compared with the protein expressed without NanoBiT strategy, the yield decreased but the stability increased (Supplementary information, Fig

NNMT is expressed in some cancer cells, which makes interpretation of inhibition complex: effects could differ by cancer type or stage, and the data are largely from models rather than long-term human study

This includes integrating the latest clinical trial data and delving into potential signaling pathways and pharmacological mechanisms

Other drugs, like Zepbound, may be more effective for some patients.