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Primarily used to treat Type 2 diabetes and assist with obesity management through weight loss, this drug class is dominated by industry leaders such as Novo Nordisk and Eli Lilly and Company

This review delineates the multifaceted mechanisms by which GLP-1RAs exert ocular benefits, including retinal ganglion cell (RGC) rescue via calcium channel and GABAergic modulation, mitochondrial protection through PINK1/Parkin-mediated mitophagy and ERK1/2-HDAC6 signaling, as well as potent anti-inflammatory effects via cytokine reduction and immune cell recruitment inhibition

This may be beneficial to patients experiencing nausea from medications that slow stomach emptying, including GLP-1 drugs

Sp1-mediated transcriptional activation of the human Pi class glutathione S-transferase promoter

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For weight loss and weight maintenance, the recommended maintenance dose is 5 mg, 10 mg, or 15 mg injected once a week