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A natural alternative to GLP-1 drugs could suit people who need intervention, but have either experienced side effects or dont have the means to access pricey drugs

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How does skin respond differently to weight loss from GLP-1s versus natural weight loss or bariatric surgery

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In Phase II clinical trials in adults with overweight or obesity, once-daily orforglipron led to 9-15% mean weight loss at 36 weeks, with a GI tolerability profile typical of the class

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