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Adherence to GLP-1 RA therapy may be improved by slowing dose escalation, as per label instructions, and setting patient expectations for possible gastrointestinal adverse outcomes that should subside over time

The largest increases in first-time CVD diagnosis following first-time GLP-1 RA prescription were seen in the group of people having overweight or BMIs between 27 to 30 (34.5% increase from 2020 to 2024)

Single-peptide vs multi-peptide activity on fibroblast migration, proliferation and ECM deposition

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Wegovy directly suppresses appetite as part of its therapeutic action, whilst bupropion may cause appetite changes as a secondary effect in some individuals

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