GLP-1RAs can cross the bloodbrain barrier and activate brain GLP-1 receptors, leading to neuroprotection by improving insulin signaling, reducing tau hyperphosphorylation, and enhancing cognitive function in diabetic and aging models
GLP-1 receptor agonists bind to receptors in the pancreas, gastrointestinal tract, and brain shortly after administration, triggering insulin secretion, appetite suppression, and delayed gastric emptying
References Nat Rev Dis Primer 2017
what will make them switch
Within peripheral blood mononuclear cells (PBMCs) of T2DM patients, T cells demonstrate increased cytotoxicity and expansion (68)
Stereotactic ablative radiation therapy for centrally located early stage or isolated parenchymal recurrences of non-small cell lung cancer: how to fly in a "no fly zone"