while we focused in our cohort and uptake calculations on individuals without diabetes, precisely isolating the non-diabetic segment within each national BMI category requires assumptions, as granular national co-prevalence data for BMI, diabetes status, and specific comorbidities are unavailable
The narrative starts to crater at the industry level (well later explore the company-specific level)
Advancements in next-generation sequencing and protein expression profiling have demonstrated that the renal targets of thiazides, i.e., Na + Cl cotransporter (NCC, encoded by SLC12A3 ) and that of bumetanide/furosemide, i.e., Na + K + 2Cl cotransporter-2 (NKCC2, encoded by SLC12A1 ) are expressed in different tissues and cells, albeit at lower levels (Di Fulvio and Alvarez-Leefmans, 2009)
Topol E
PMID 17186181
doi: 10.2337/diacare.28.5.1092, 24 DicksonS