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"Obesity should be treated like any other chronic disease -- with effective and safe approaches that target underlying disease mechanisms, and these results underscore that tirzepatide may be doing just that," Jastreboff said in a statement

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Drug-induced ER stress and the oxidative stress response are sensitive to TNF-mediated hepatotoxicity [1]

Prior to VENTURE, Viking initiated a Phase 1 SAD and MAD clinical trial of VK2735 in 2022

The FDA label carries warnings about primary pulmonary hypertension and valvular heart disease, though these are rare