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Melanotan II is a synthetic peptide analogue investigated for its interaction with melanocortin receptors, particularly in studies related to pigmentation and melanin production

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It is used off-label in clinical and aesthetic medicine

When compared head-to-head against Matrixyl 3000 (a widely used synthetic peptide in high-end skincare), GHK-Cu still achieved a 31.6% greater reduction in wrinkle volume

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N Z Med J 2016;129:67-75