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A widely cited microarray screen reported that GHK exposure of human fibroblast cultures altered expression of more than 4,000 genes, with pathway analysis identifying TGF-, integrin, and ubiquitin-proteasome signaling as enriched among GHK-responsive transcripts

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Comarmond, C

Follow-up Repeat broad labs after 8-12 weeks if systemic use continues or symptoms change

TGF- is involved in regulating a variety of aspects of host defence to injury

Activation of genes encoding antioxidant enzymes such as catalases and GST1 was detected in the tissue surrounding the initial infection site (Schenk et al., 2000)