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Without being bound to copper, GHK has been shown to be a quencher of cytotoxic end products of lipid peroxidation such as ,-4-hydroxy-trans-2-nonenal and acrolein, which can be associated with severe pathologies such as diabetes and neurodegenerative disease [18- 19]

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Some of these may increase the risk of OH

Notably, individuals at the extremes of age, both infants and the elderly, as well as those with pre-existing comorbidities, particularly cardiopulmonary disorders, are at markedly increased risk (490)

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280 Each study assessed physical activity in a different manner