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Science 125:884885 Mller J (2003) Effects of growth hormone on fluid homeostasis
This vasodilatory effect is hypothesized to alleviate vascular dysregulation associated with conditions like glaucoma, particularly normal-tension glaucoma (NTG), where chronic blood flow dysfunction contributes to optic neuropathy [152]
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Understanding the connection between MTHFR and longevity requires moving past the standard homocysteine narrative to the full mechanistic picture: how reduced methylation capacity accelerates the epigenetic aging clock, how it depletes the glutathione substrate pool, how it uncouples eNOS and accelerates vascular aging, how it impairs DNA repair through uracil misincorporation, and how it reduces the methylation-dependent gene regulation that FOXO3 and SIRT1 require to execute their longevity programs
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