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A genome-wide CRISPR death screen identifies genes essential for oxidative phosphorylation

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Without copper, tyrosinase cannot catalyse the hydroxylation of L-tyrosine, and melanin synthesis slows

Bahamonde C, Conde C, Agera E et al (2014) Elevated melatonin levels in natalizumab-treated female patients with relapsing-remitting multiple sclerosis: relationship to oxidative stress