The honest answer is that retatrutide has not been studied enough in cardiac patients to give a definitive green light
These are not marginal products they include some of the highest-revenue branded drugs in the U.S
Medicares current policy, which excludes anti-obesity medications unless prescribed for another condition like diabetes, exacerbates this issue 2
For instance, in a 2021 study, 80 percent of adults who took phentermine over the course of six months lost at least five percent of their body fat, with no major side effects (18)
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However, in isolated mouse hearts perfused with the sAC inhibitor KH7, we observed loss of cardioprotection with GLP-1(2836), but not GLP-1, as measured by LVDP at the end of the reperfusion (25.2 1.7 mmHg, n = 3, vs