glp 1 gip tirzepatide is glp-1 use tripled among non-diabetics, reaching $5.8B in 2022 Frontiers The dual agonist action of

Furthermore, its short half-life of less than 3 h (Min et al., 2025) necessitates twice-daily injections to maintain efficacy, which can be a limiting factor for long-term patient adherence

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Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis

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