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Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist approved by the FDA for the treatment of type 2 diabetes mellitus and chronic weight management

In healthy young adults (yellow curves), robust high-amplitude circadian rhythms are evident in diverse physiological variables (activity levels, core body temperature, SCN firing rate, hormonal secretion such as melatonin and cortisol, glucose metabolism, etc.) across the 24-h day

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JAMA 297(12):13191331

Disclosures Ildiko Lingvay has performed consultancy for AstraZeneca, Boehringer Ingelheim Pharmaceuticals, Inc., Eli Lilly and Company, Intarcia Therapeutics, Janssen Pharmaceuticals, Inc., MannKind Corporation, Novo Nordisk A/S, Sanofi, TARGET PharmaSolutions and Valeritas, Inc

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