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Nature 402, 656660
However, during high-fat diet (HFD) feeding, obesity and insulin resistance, the accumulation of medium-chain and long-chain acylcarnitines due to incomplete -oxidation may negatively regulate the expression of nuclear-encoded mitochondrial genes, further reducing mitochondrial number and function and creating a vicious metabolic cycle [33]
Importantly, most patients can safely continue their GLP-1 therapy without interruption, except in cases of pronounced GI side effects or other risk factors
The best one depends on your individual health history and how you tolerate the medication
J Exp Bot 57:37553766
Switching between GLP-1 medications is possible under provider supervision
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