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For example, Angong Niuhuang Wan inhibits the accumulation of ROS and Fe 2+ and improves mitochondrial dysfunction and BBB structural integrity by activating the PPAR/AKT/GPX4 pathway, thereby enhancing neurological function in rats with ischemic stroke and reducing cerebral infarction volume

Risk of bias assessment for blinding of participants and personnel, incomplete outcome data, selective reporting, and overall risk of bias are for the primary outcome (change in HbA1c)

and they help regulate blood glucose levels by enhancing insulin secretion when blood sugar rises

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