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Despite improvements in surgical techniques and perioperative care, the development of perioperative organ dysfunction such as acute heart failure, stroke, acute kidney injury (AKI), or liver injury remains directly associated with worse outcomes and significant mortality ( It is now recognized that excessive inflammation plays a pivotal role in perioperative organ damage ( Mitochondria have emerged as central orchestrators of this perioperative inflammationimmunosuppression continuum

SAMe not only plays a role in methylation

Clinical , vol

S., Song, M

10.1038/nature05111 20 Hoppins S., Edlich F., Cleland M