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These are one of, if not the most rigorously studied class of peptides ever, with many large, placebo-controlled, randomized trials that followed over the past twenty years from the original GLP-1 drugs such as exenatide, approved by the FDA in 2005
doi: 10.1158/0008-5472.CAN-16-2860 57 TanJKMaciaLMackayCR
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